benastatin B Chemical Properties

Boiling point:

759.3±60.0 °C(Predicted)

Density 

1.372±0.06 g/cm3(Predicted)

storage temp. 

-20°C

pka

2.99±0.40(Predicted)

form 

A powder

benastatin B Usage And Synthesis

Uses

Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC50 of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC50 of 79 μg/mL[1][2].

References

[1] Aoyama T, et al., Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B. J Antibiot (Tokyo). 1992 Sep;45(9):1391-6. DOI:10.7164/antibiotics.45.1391
[2] Tsakem B, et al., Structures, biosynthesis and biological activities of benastatins, anthrabenzoxocinones and fredericamycins. Bioorg Chem. 2024 Sep;150:107572. DOI:10.1016/j.bioorg.2024.107572

benastatin B(138968-86-2)Related Product Information

• 4-Methylsalicylic acid
• emodin anthrone
• 4-(3-METHYLPHENYL)BENZALDEHYDE
• 3,3',4,4'-TETRAMETHYLBIPHENYL
• 10,10-Dimethylanthrone
• 4-PHENYL ETHYL BENZOIC ACID
• 3-ISOPROPYLBIPHENYL
• 2,2',5,5'-TETRAMETHYLBIPHENYL
• 4-Benzoylbiphenyl
• 3-PHENYLSALICYLIC ACID
• 4-(4-N-BUTYLPHENYL)BENZALDEHYDE
• 2'-METHYLBIPHENYL-3-CARBOXYLIC ACID
• 3',4'-DIMETHYL-BIPHENYL-3-CARBALDEHYDE
• benastatin B
• 4'-ETHYLBIPHENYL-4-CARBOXALDEHYDE
• (4'-METHYLBIPHENYL-3-YL)-METHANOL
• 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID
• 1,2-BIS(3,4-DIMETHYLPHENYL)ETHANE