tetrathiomolybdate
tetrathiomolybdate Basic information
- Product Name:
- tetrathiomolybdate
- Synonyms:
-
- tetrathiomolybdate
- THIOMOLYBDATE
- 18198-15-7 (Di-hydrochloride salt)
- Molybdate(2-), tetrathioxo-, (T-4)- (9ci)
- Tetrathioxomolybdate(2-)
- tetrathiomolybdate(2-)
- CAS:
- 16330-92-0
- MF:
- MoS4
- MW:
- 0
- EINECS:
- 928-805-0
- Mol File:
- 16330-92-0.mol
tetrathiomolybdate Chemical Properties
- storage temp.
- Store at -20°C
tetrathiomolybdate Usage And Synthesis
Uses
Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].
Definition
ChEBI: Tetrathiomolybdate(2-) is a molybdenum coordination entity. It has a role as a copper chelator.
in vivo
Tetrathiomolybdate (0.2 mg/mouse/day; p.o.; for 10 weeks) protects mice from collagen-induced arthritis with preventive effect[1].
Tetrathiomolybdate (0.03 mg/mL; medicined in water; p.o.; 8 weeks) inhibits the progress of collagen-induced arthritis in mice by reducing swelling and erythema[1].
| Animal Model: | Collagen-induced arthritis model in mice[1] |
| Dosage: | 0.2 mg/mouse/day or 0.03 mg/mL, added in water |
| Administration: | Oral gavage, for 10 weeks; Collagen injected at weeks 2 |
| Result: | Showed significant preventive effect and protective effect in mice. |
References
[1] Zeng C, et al. Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes. Exp Biol Med (Maywood). 2008 Aug;233(8):1021-5. DOI:10.3181/0801-RM-10
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