AQ 148
AQ 148 Basic information
- Product Name:
- AQ 148
- Synonyms:
-
- AQ 148
- (2S)-1-[(S)-benzamido-benzyl-methylazaniumyl]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-phenylbutan-2-olate
- CAS:
- 178820-70-7
- MF:
- C30H37N3O4
- MW:
- 503.639
- Mol File:
- 178820-70-7.mol
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AQ 148 Usage And Synthesis
Description
AQ 148 is a potent competitive inhibitor of HIV-1 PR.
Uses
AQ148 is a HIV-1 protease inhibitor (Ki=137 nM). The IC50 values ??of AQ148 for the inhibition of HIV-1, HIV-2 and SIV aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively[1].
References
[1] Rutenber, et al. "A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere." Bioorganic & medicinal chemistry 4.9 (1996): 1545-1558. DOI:10.1016/0968-0896(96)00147-2