Safety Information

RIDADR 

3172

HazardClass 

6.1(a)

PackingGroup 

I

BACCHARIN Usage And Synthesis

Enzyme inhibitor

This anti-leukemia agent (FW = 562.61 g/mol; CAS 61251-97-6), also named (2'S,3'R,4'S, 7'R,9R,10S)-7'-deoxo-2'-deoxy-2',3':9,10-bisoxy-9,10- dihydro-4'-hydroxy-7'-[(R)-1-hydroxyethyl]verrucarin A, from the toxic South American plant known as green propolis (Baccharis megapotamica), is a likely mycotoxin that was later modified by Baccharis megapotamica. Baccharin is also a potent competitive inhibitor (Ki = 56 nM) of human aldo-keto reductase (AKR) 1C3, also known as 17β-hydroxysteroid dehydrogenase (Type 5) and prostaglandin F synthase. AKR is regarded as a druggable target in the treatment of prostate and breast cancers. Baccharin shows no significant inhibition toward the AKR1C1, AKR1C2, and AKR1C4 isoforms. Moreover, non-prenyl analogues of baccharin as selective and potent inhibitors for AKR1C3.

BACCHARIN(61251-97-6)Related Product Information

• (R)-(+)-2,3-EPOXYPROPYL HEXYL ETHER
• 2,2'-hexane-1,6-diylbisoxirane
• 1,6-Hexanediol diglycidyl ether
• 2-(S)-Hydroxy-3-methylbutyric acid methyl ester
• DIGLYCIDYL ETHER
• Neopentyl glycol diglycidyl ether
• BACCHARIN
• 1,2,6,7-DIEPOXYHEPTANE
• 2-[(cyclopentyloxy)methyl]oxirane
• [(cyclohexyloxy)methyl]oxirane
• 2-{[(2-isopropyl-5-methylcyclohexyl)oxy]methyl}oxirane
• ETHYL (2S,3S)-2,3-EPOXY-3-METHYLPROPANOATE
• (R)-(+)-2,3-EPOXYPROPYL PENTYL ETHER
• METHYL (2S)-GLYCIDATE
• 1,2,7,8-DIEPOXYOCTANE
• ETHYL (2S)-2,3-EPOXYPROPANOATE