METHYL 3-CHLOROPHENYLACETATE Chemical Properties

Boiling point:

120-121℃ (9 Torr)

Density 

1.197±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.5225-1.5245

Flash point:

108.8±15.8℃

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

color 

Clear colorless to light yellow

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25-36/37/39

HS Code 

29153900

MSDS

• Language:English Provider:ACROS

METHYL 3-CHLOROPHENYLACETATE Usage And Synthesis

Chemical Properties

clear slightly yellowish liquid

Synthesis

GENERAL METHOD: Thionyl chloride (1.06 mL, 14.63 mmol) was added slowly and dropwise to a solution of 3-chlorophenylacetic acid (1 g, 4.877 mmol) in methanol (10 mL) at 0 °C. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in a solvent mixture of ethyl acetate and water. The aqueous phase was extracted with ethyl acetate and the combined organic phases were washed with aqueous sodium bicarbonate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl m-chlorophenylacetate (6a-f).

References

[1] Tetrahedron, 1997, vol. 53, # 38, p. 13149 - 13164
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 13, p. 2843 - 2866
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 17, p. 2701 - 2706
[4] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 4, p. 1679 - 1693
[5] Tetrahedron Letters, 2003, vol. 44, # 2, p. 331 - 334

METHYL 3-CHLOROPHENYLACETATE(53088-68-9)Related Product Information

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