Reboxetine mesylate Chemical Properties

Melting point:

136-139 °C

Boiling point:

443.7±30.0 °C(Predicted)

Density 

1.113±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

Chloroform (Slightly), Water (Slightly)

form 

Solid

pka

8.37±0.40(Predicted)

color 

Off-White to Pale Beige

CAS DataBase Reference

71620-89-8(CAS DataBase Reference)

Reboxetine mesylate Usage And Synthesis

Uses

Antidepressant (selective noradrenaline reuptake inhibitor).

Uses

Reboxetine can be used in biological study of the involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test.

Definition

ChEBI: Reboxetine is an aromatic ether.

brand name

Edronax (Pharmacia & Upjohn).

Biological Activity

Potent and selective inhibitor of noradrenalin uptake (K i values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α -adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active, clinically used antidepressant.

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