Xanomeline Chemical Properties

Boiling point:

397.0±42.0 °C(Predicted)

Density 

1.101±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

H2O: soluble10mg/mL, clear (warmed)

form 

powder

pka

7.34±0.40(Predicted)

color 

off-white

InChIKey

JOLJIIDDOBNFHW-UHFFFAOYSA-N

Safety Information

WGK Germany 

3

Xanomeline Usage And Synthesis

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

Uses

Alzheimer’s disease treatment (cholinergic agonist).

Definition

ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

Xanomeline(131986-45-3)Related Product Information

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