2-AMINO-4-FLUOROPYRIDINE Chemical Properties

Melting point:

102 °C

Boiling point:

211.5±20.0 °C(Predicted)

Density 

1.257±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

form 

Solid

pka

6.42±0.11(Predicted)

color 

Pale yellow

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C5H5FN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)

InChIKey

WCCFLOQQACDOAX-UHFFFAOYSA-N

SMILES

C1(N)=NC=CC(F)=C1

Safety Information

HazardClass 

IRRITANT

HS Code 

2933399990

2-AMINO-4-FLUOROPYRIDINE Usage And Synthesis

Description

2-Amino-4-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Properties

White powder

Uses

It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Uses

2-Amino-4-fluoropyridine is an important intermediate for organic synthesis and pharmaceuticals.

Synthesis

General procedure for the synthesis of 2-amino-4-fluoropyridine from 2-amino-4-chloropyridine: 28 g of 2-amino-4-chloropyridine was dissolved in 100 ml of N,N-dimethylformamide, followed by the addition of 46 g of sodium fluoride. The reaction mixture was heated to 140°C and kept reacting for 5 to 8 hours. Upon completion of the reaction, the mixture was cooled to 80 °C and the solvent was subsequently recovered by distillation under reduced pressure. The residue was dissolved in dichloromethane and washed with saturated saline. The organic phase was separated and after evaporation of the solvent, recrystallized from ethanol to give 22 g of white solid 2-amino-4-fluoropyridine in 90% yield.

References

[1] Patent: CN108440402, 2018, A. Location in patent: Paragraph 0008; 0020; 0023-0024; 0027-0028; 0031

2-AMINO-4-FLUOROPYRIDINE(944401-77-8)Related Product Information

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