2-CHLORO-6-METHYLPHENOL Chemical Properties

Melting point:

130 °C

Boiling point:

86 °C

Density 

1,201 g/cm³

refractive index 

1.5450

Flash point:

72°C

storage temp. 

Sealed in dry,Room Temperature

pka

8.84±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Water Solubility 

Soluble in water (24 mg/ml at 25°C).

BRN 

774623

CAS DataBase Reference

87-64-9(CAS DataBase Reference)

EPA Substance Registry System

6-Chloro-o-cresol (87-64-9)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

21/22-36/38-36/37/38-22-38

Safety Statements 

26-28-36/37/39-23

RIDADR 

3437

RTECS 

GO7120100

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

II

HS Code 

2908190090

MSDS

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2-CHLORO-6-METHYLPHENOL Usage And Synthesis

Chemical Properties

Coloroless to yellow liquid

Uses

2-Chloro-6-methylphenol is s an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.

Synthesis

GENERAL METHOD: Molten o-cresol or m-cresol (5.41 g, 50.0 mmol), AlCl3 (0.25 g), and catalyst (100 mg) were added to a dry 50 mL round bottom flask. Thionyl chloride (4.66 mL, 57.7 mmol) was added slowly and dropwise over a period of 2 h via a pressure-equilibrated dropping funnel. The reaction mixture was stirred continuously for 2 hours and then the reaction was quenched with 20 mL of water. The reaction mixture was post-treated by drying the crude product to constant weight and subsequently analyzed by quantitative gas chromatography (GC).

References

[1] Synthetic Communications, 2002, vol. 32, # 2, p. 279 - 286
[2] Synlett, 2011, # 11, p. 1537 - 1542
[3] Journal of the Chemical Society, Chemical Communications, 1980, # 1, p. 8 - 9
[4] Journal of the Chemical Society, Chemical Communications, 1980, # 1, p. 8 - 9
[5] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1928, vol. 60, p. 161

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