4-Chloro-2-methylphenol Chemical Properties

Melting point:

43-46 °C(lit.)

alpha 

22 º (c=8,6N HCl)

Boiling point:

220-225 °C(lit.)

Density 

1.20

vapor pressure 

26.66Pa at 19.85℃

refractive index 

1.5449 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

pka

9.87±0.18(Predicted)

color 

white to brown

Water Solubility 

<0.1 g/100 mL at 15 ºC

BRN 

1906684

InChIKey

RHPUJHQBPORFGV-UHFFFAOYSA-N

LogP

3.09 at 20℃

CAS DataBase Reference

1570-64-5(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 4-chloro-2-methyl-(1570-64-5)

EPA Substance Registry System

4-Chloro-2-methylphenol (1570-64-5)

Safety Information

Hazard Codes 

T,C,N,Xn

Risk Statements 

23-35-50-38-21/22

Safety Statements 

26-36/37/39-45-61-28

RIDADR 

UN 3437 6.1/PG 2

WGK Germany 

2

RTECS 

GO7120000

Hazard Note 

Toxic/Corrosive

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29081990

Hazardous Substances Data

1570-64-5(Hazardous Substances Data)

Toxicity

mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03270,

MSDS

• Language:English Provider:4-Chloro-o-cresol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Chloro-2-methylphenol Usage And Synthesis

Chemical Properties

Off-white to slightly brownish crystalline solid

Uses

4-Chloro-2-methylphenol is a transformation/degredation product of herbicides found in the environment through landfills and runoff.

Definition

ChEBI: 4-chloro-2-methylphenol is a member of the class of phenols that is o-cresol in which the hydrogen para to the hydroxy group is replaced by a chlorine. It is a member of phenols and a member of monochlorobenzenes. It is functionally related to an o-cresol.

Application

4-Chloro-2-methylphenol is an important pharmaceutical intermediate ingredient used in the manufacture of herbicides (Mecoprop, MCPA, and MCPB), as an additive tracer for resist plasma etching. It is used as a closed system intermediate in the production of phenoxy herbicides. It is also used as a disinfectant or bactericide.

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 5215, 1989 DOI: 10.1016/S0040-4039(01)93745-1

General Description

Dark red flakes with waxy texture. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Chloro-2-methylphenol can react vigorously with concentrated sodium hydroxide solutions. Also reacts with other bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys [NTP, 1992)]. A large quantity left in contact with concentrated sodium hydroxide solution for 3 days reacted violently, attaining red heat and evolving fumes that ignited explosively. The heat of reaction dissipated poorly because of the high viscosity of the mixture [Quart. Safety Summ., 1957, 28, 39].

Fire Hazard

4-Chloro-2-methylphenol is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Purify the phenol by crystallisation from pet ether (m 51o) and by zone melting. [Beilstein 6 H 359, 6 I 174, 6 II 332, 6 III 1264, 6 IV 1987.]

4-Chloro-2-methylphenol(1570-64-5)Related Product Information

• 2-Chloro-5-chloromethylpyridine
• Cresol
• 3-Trifluoromethylphenol
• m-Cresol
• 4-CHLORO-2-METHYLBENZOIC ACID
• 3-Ethylphenol
• o-Cresol
• Xylenol
• p-Cresol
• 2,6-Dimethylphenol
• 4-Chloro-3-methylphenol
• MECOPROP
• 2,2'-METHYLENEBIS(4-CHLOROPHENOL)
• 4-CHLORO-2-ISOPROPYL-5-METHYLPHENOL
• 2-Methyl-4-chlorophenoxyacetic acid
• 5-Chlorosalicylaldehyde
• MCPB
• Difluorochloromethane