8-Quinolinecarbaldehyde Chemical Properties

Melting point:

95-96°C

Boiling point:

314.3±15.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

3.45±0.17(Predicted)

color 

Light orange to Yellow to Green

Water Solubility 

Insoluble in water.

Sensitive 

Air Sensitive

BRN 

113039

InChI

InChI=1S/C10H7NO/c12-7-9-4-1-3-8-5-2-6-11-10(8)9/h1-7H

InChIKey

OVZQVGZERAFSPI-UHFFFAOYSA-N

SMILES

N1C2C(=CC=CC=2C=O)C=CC=1

CAS DataBase Reference

38707-70-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36/38-43

Safety Statements 

26-37/39-36/37

HazardClass 

IRRITANT

HS Code 

29334900

MSDS

• Language:English Provider:ALFA

8-Quinolinecarbaldehyde Usage And Synthesis

Chemical Properties

Off-white solid

Uses

Quinoline-8-carboxaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Synthesis

General method: 8-quinoline methanol was dissolved in anhydrous DMSO (10 v/v), 1 equivalent of polymer bromide was added, and the reaction mixture was stirred at room temperature for the indicated time (see Table 1). Upon completion of the reaction, the mixture was filtered and the polymer bed was washed with DMSO. The DMSO layers were combined and the reaction was quenched with an ice-water mixture and subsequently extracted with ether. The ether layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated to give pure 8-quinolinecarboxaldehyde. All products were structurally confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS).

References

[1] Tetrahedron Letters, 2011, vol. 52, # 51, p. 6971 - 6973
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 10, p. 3480 - 3484
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 31, p. 9084 - 9087
[4] Angew. Chem., 2016, vol. 128, # 31, p. 9230 - 9233,4

8-Quinolinecarbaldehyde(38707-70-9)Related Product Information

• Quinoline Yellow
• Isoquinoline
• 8-Hydroxyquinoline
• QUINOLINE SULPHATE
• 2-Quinolinecarboxaldehyde
• Quinhydrone
• 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
• Quinclorac
• Formaldehyde
• Ethoxyquin
• quinoline-2-carboxiMidaMide hydrochloride
• 8-Quinolineboronic acid
• 8-acetylquinoline
• ISOQUINOLINE-8-CARBALDEHYDE
• ISOQUINOLINE-1-CARBALDEHYDE
• 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBALDEHYDE
• 8-Hydroxyquinoline-2-carboxaldehyde
• 8-Quinolinecarboxylic acid