3-AMINO-4-BROMO-1H-INDAZOLE Chemical Properties

Melting point:

142-144℃

Boiling point:

431.3±25.0 °C(Predicted)

Density 

1.867±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Slightly soluble.

form 

Crystalline Powder

pka

13.68±0.40(Predicted)

color 

Off-white to brown to gray

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN2811

HazardClass 

IRRITANT

HS Code 

29339980

3-AMINO-4-BROMO-1H-INDAZOLE Usage And Synthesis

Uses

Microwave heating of 2-halobenzaldehydes or 2-haloacetophenones with phenylhydrazines at 160°C for 10 min quantitatively yielded the arylhydrazones, which were further cyclized to give 1-aryl-1H-indazoles via CuI/diamine-catalyzed N-arylation under microwave heating (160°C, 10 min). Good to excellent yields were observed for 2-iodo, 2-bromo, and 2-chloro benzaldehydes or acetophenones.

Synthesis

A solution of 2-fluoro-6-bromobenzonitrile (22.0 mmol) and 98% hydrazine hydrate (90.0 mmol) in n-butanol (15 ml) was stirred at reflux for 7 hours. The mixture was cooled to room temperature. The resulting mixture was concentrated under reduced pressure to a volume of 5 ml. water was added to the resulting mixture. The solid product was precipitated. The precipitate was filtered. Wash the precipitate with water. Dry the precipitate. The precipitate was purified by crystallization from methanol to give 4-bromo-1H-indazol-3-amine.

3-AMINO-4-BROMO-1H-INDAZOLE(914311-50-5)Related Product Information

• Tiotropium bromide
• 3-Fluoro-4-broMo-6-aMinotoluene
• 2,6-Dibromo-4-nitroaniline
• 4-Bromo-1H-indazole
• 3-AMINO-4-BROMO-1H-INDAZOLE