4-Methanesulfonyl-piperidine Chemical Properties

Boiling point:

336.9±31.0 °C(Predicted)

Density 

1.18±0.1 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

9.22±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

4-Methanesulfonyl-piperidine Usage And Synthesis

Synthesis

General procedure for the synthesis of 4-methylsulfonylpiperidine from tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate (Step 4): tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate obtained in Step 3 of Reference Example 12 was dissolved in ethyl acetate (16 mL), followed by the addition of a 4.0 mol/L dioxane solution of hydrogen chloride (12 mL). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the precipitated solid was collected by filtration to afford the target product 4-(methylsulfonyl)piperidine (1.4 g, 76% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 270 MHz) with the following chemical shifts δ (ppm): 3.41-3.31 (m, 3H), 2.97 (s, 3H), 2.97-2.82 (m, 2H), 2.18-2.13 (m, 2H), 1.92-1.73 (m, 2H).

References

[1] Patent: EP1642880, 2006, A1. Location in patent: Page/Page column 112
[2] Patent: US2003/100567, 2003, A1

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• ETHYL 4-[(4-METHOXYPHENYL)SULFONYL]-1-(4-METHYLBENZYL)-4-PIPERIDINECARBOXYLATE
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