N-OLEOYL-D-SPHINGOSINE Chemical Properties

storage temp. 

−20°C

solubility 

Chloroform: Soluble; DMF: 0.15 mg/ml

form 

lyophilized powder

color 

White to off-white

BRN 

6283861

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

N-OLEOYL-D-SPHINGOSINE Usage And Synthesis

Description

C18:1 Ceramide is a naturally occurring ceramide. Levels of C18:1 ceramide are elevated in overweight and insulin-resistant mice and cattle. C18:1 Ceramide is also increased in the plasma and ovarian tissue of patients with advanced ovarian cancer.

Uses

N-Oleoyl-D-erythro-sphingosine is a member of the ceramide family.

Definition

ChEBI: N-oleoylsphingosine is a N-acylsphingosine in which the ceramide N-acyl group is specified as oleoyl. It has a role as a mouse metabolite. It is functionally related to an oleic acid.

References

[1] MINI P SAJAN. Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.[J]. Journal of Lipid Research, 2015: 70-80. DOI: 10.1194/jlr.m052977
[2] J.E. RICO . Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation[J]. Journal of Dairy Science, 2015, 98 11: Pages 7757-7770. DOI: 10.3168/jds.2015-9519
[3] PAWE? KNAPP . Plasma and ovarian tissue sphingolipids profiling in patients with advanced ovarian cancer[J]. Gynecologic oncology, 2017, 147 1: Pages 139-144. DOI: 10.1016/j.ygyno.2017.07.143

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