STE-MPKKKPTPIQLNP-NH2 Chemical Properties

storage temp. 

-20°C

form 

lyophilized solid

color 

white

Water Solubility 

water: 1mg/mL
DMSO: 5mg/mL

STE-MPKKKPTPIQLNP-NH2 Usage And Synthesis

Uses

STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable ERK1/2 inhibitor (IC50: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation[1][2].

Biological Activity

Cell permeable: yes', 'Primary Target
MEK', 'Product does not compete with ATP.', 'Reversible: yes

References

[1] Li G, et al. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec;13(12):2109-17. DOI:10.1038/sj.cdd.4401970
[2] Whiteman M, et al. Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Osteoarthritis Cartilage. 2006 May;14(5):460-70. DOI:10.1016/j.joca.2005.11.002

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