Dorzolamide Chemical Properties

Boiling point:

575.8±60.0 °C(Predicted)

Density 

1.53±0.1 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: soluble5mg/mL (clear solution, warmed)

pka

pKa 6.35 (Uncertain);8.50 (Uncertain)

form 

powder

color 

white to beige

optical activity

[α]/D -25 to -35°, c = 1 in methanol

CAS DataBase Reference

120279-96-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

RTECS 

XJ9095169

Dorzolamide Usage And Synthesis

Uses

Carbonic anhydrase inhibitor.

Uses

Dorzolamide is an intermediate in synthesizing N-Acetyl Dorzolamide (A173640), a useful synthetic compound.

Definition

ChEBI: 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration . A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.

brand name

Trusopt (Merck).

Dorzolamide(120279-96-1)Related Product Information

• Dorzolamide Hydrochloride
• METSULFURON METHYL
• Methyl acetate
• Acrylamide
• Erucamide
• Boc-D-Glutamine
• Nicotinamide
• 1,4-Dioxane
• Thiophanate-methyl
• Tribenuron methyl
• Ceramide
• N,N-Dimethylformamide
• Polyamide
• Methyl salicylate
• Selenium dioxide
• Kresoxim-methyl
• Polyacrylamide
• (4S)-4-Acetamide-5,6-Dihydro-6-Methyl-2-Sulfonamide-Thio[2,3-B]Thiopyran7,7Dioxide