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CYCLOOCTANONE

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CYCLOOCTANONE Basic information

Product Name:
CYCLOOCTANONE
Synonyms:
  • TIMTEC-BB SBB008888
  • CYCLOOCTAN-1-ONE
  • CYCLOOCTANONE
  • Cyclooctanone,97%
  • Azelaone
  • Cyclooctanone,98%
  • Cyclooctanone, 98% 100GR
  • Cyclooctanone, 98% 500GR
CAS:
502-49-8
MF:
C8H14O
MW:
126.2
EINECS:
207-940-2
Product Categories:
  • Aliphatics, Pharmaceuticals, Intermediates & Fine Chemicals
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
Mol File:
502-49-8.mol
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CYCLOOCTANONE Chemical Properties

Melting point:
32-41 °C (lit.)
Boiling point:
195-197 °C (lit.)
Density 
0.958 g/mL at 25 °C (lit.)
refractive index 
1.4694
Flash point:
163 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
15g/l
form 
Crystalline Low Melting Solid
color 
Colorless to white
PH
7 (15g/l, H2O, 20℃)
Water Solubility 
Soluble in water at 20°C 15g/L. Soluble in acetone, alcohol, chloroform, methanol and benzene.
BRN 
1280738
InChIKey
IIRFCWANHMSDCG-UHFFFAOYSA-N
LogP
2.11
CAS DataBase Reference
502-49-8(CAS DataBase Reference)
EPA Substance Registry System
Cyclooctanone (502-49-8)
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Safety Information

Hazard Codes 
C,Xi
Risk Statements 
34-52/53-36/37/38
Safety Statements 
45-36/37/39-26-61
RIDADR 
1759
WGK Germany 
3
RTECS 
GX9800000
TSCA 
Yes
HazardClass 
8
HS Code 
29142990

MSDS

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CYCLOOCTANONE Usage And Synthesis

Chemical Properties

colorless to white crystalline low melting solid

Uses

Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level. It is also used in the synthesis of 14-membered lactones.

Synthesis Reference(s)

Journal of the American Chemical Society, 92, p. 5276, 1970 DOI: 10.1021/ja00720a078
The Journal of Organic Chemistry, 49, p. 3912, 1984 DOI: 10.1021/jo00195a007
Tetrahedron Letters, 36, p. 2921, 1995 DOI: 10.1016/0040-4039(95)00467-Q

Purification Methods

Purify the ketone by sublimation after drying with Linde type 13X molecular sieves. The semicarbazone has m 168-169o (from dioxane) [Kohler et al. J Am Chem Soc 61 1060 1939]. The oxime has m 36-37o after subliming at high vacuum or distillation and has b 128-129o /14mm. The iso-oxime has m 72-73o [Ruzicka et al. Helv Chim Acta 32 548 1949]. [Beilstein 7 III 77, 7 IV 49.]

CYCLOOCTANONE Preparation Products And Raw materials

Raw materials

CYCLOOCTANONESupplier

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