CYCLOOCTANONE Chemical Properties

Melting point:

32-41 °C (lit.)

Boiling point:

195-197 °C (lit.)

Density 

0.958 g/mL at 25 °C (lit.)

refractive index 

1.4694

Flash point:

163 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

15g/l

form 

Crystalline Low Melting Solid

color 

Colorless to white

PH

7 (15g/l, H2O, 20℃)

Water Solubility 

Soluble in water at 20°C 15g/L. Soluble in acetone, alcohol, chloroform, methanol and benzene.

BRN 

1280738

InChIKey

IIRFCWANHMSDCG-UHFFFAOYSA-N

LogP

2.11

CAS DataBase Reference

502-49-8(CAS DataBase Reference)

EPA Substance Registry System

Cyclooctanone (502-49-8)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-52/53-36/37/38

Safety Statements 

45-36/37/39-26-61

RIDADR 

1759

WGK Germany 

3

RTECS 

GX9800000

TSCA 

Yes

HazardClass 

8

HS Code 

29142990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

CYCLOOCTANONE Usage And Synthesis

Chemical Properties

colorless to white crystalline low melting solid

Uses

Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level. It is also used in the synthesis of 14-membered lactones.

Synthesis Reference(s)

Journal of the American Chemical Society, 92, p. 5276, 1970 DOI: 10.1021/ja00720a078
The Journal of Organic Chemistry, 49, p. 3912, 1984 DOI: 10.1021/jo00195a007
Tetrahedron Letters, 36, p. 2921, 1995 DOI: 10.1016/0040-4039(95)00467-Q

Purification Methods

Purify the ketone by sublimation after drying with Linde type 13X molecular sieves. The semicarbazone has m 168-169o (from dioxane) [Kohler et al. J Am Chem Soc 61 1060 1939]. The oxime has m 36-37o after subliming at high vacuum or distillation and has b 128-129o /14mm. The iso-oxime has m 72-73o [Ruzicka et al. Helv Chim Acta 32 548 1949]. [Beilstein 7 III 77, 7 IV 49.]

CYCLOOCTANONE(502-49-8)Related Product Information

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