DL-BUTHIONINE-[S,R]-SULFOXIMINE
DL-BUTHIONINE-[S,R]-SULFOXIMINE Basic information
- Product Name:
- DL-BUTHIONINE-[S,R]-SULFOXIMINE
- Synonyms:
-
- DL-BUTHIONINE (R,S)-SULFOXIMINE
- DL-BUTHIONINE-[S,R]-SULFOXIMINE
- DL-BUTHIONINE (S,R)-SULPHOXIME
- DL-BUTHIONINE-SULFOXIMINE
- 2-amino-4-(s-butylsulfonimidoyl)-butanoicaci
- 2-amino-4-(s-butylsulfonimidoyl)butanoicacid
- buthioninesulfoxamine
- buthioninesulfoximine
- CAS:
- 5072-26-4
- MF:
- C8H18N2O3S
- MW:
- 222.31
- EINECS:
- 628-045-7
- Product Categories:
-
- Glutathione S-Transferase Agents
- Sulfur & Selenium Compounds
- D to
- Drug and Xenobiotic Metabolism
- Enzyme Inhibitors by Enzyme
- Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism
- Substrates, Inducers, Inhibitors
- Mol File:
- 5072-26-4.mol
DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties
- Melting point:
- 215 °C (dec.)(lit.)
- Boiling point:
- 382.3±52.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL, clear, colorless
- form
- Fluffy Powder
- color
- White
- Merck
- 13,1520
- BRN
- 2367136
- CAS DataBase Reference
- 5072-26-4(CAS DataBase Reference)
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
DL-BUTHIONINE-[S,R]-SULFOXIMINE Usage And Synthesis
Chemical Properties
White Crystalline Solid
Uses
A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Uses
DL-Buthionine-sulfoximine is suitable for use to:
- examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
- investigate the effect of BSO on development of bovine embryos
- inhibit GSH in several studies
- investigate the effect of GSH synthesis on oocyte maturation
Uses
Biological tool for depletion of glutathione.
Definition
ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
General Description
DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Biochem/physiol Actions
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).
DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials
Preparation Products
DL-BUTHIONINE-[S,R]-SULFOXIMINESupplier
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DL-BUTHIONINE-[S,R]-SULFOXIMINE(5072-26-4)Related Product Information
- 1-Dodecanethiol
- 4-Methyl-2-pentanone
- D,L-BUTHIONINE
- 4-(TERT-BUTYL)BENZENE-1-CARBOTHIOAMIDE
- Butylate
- Tetrabutylammonium hydrogen sulfate
- S-Butyrylthiocholine Iodide
- Terbufos
- TETRA-N-BUTYLTHIURAM DISULFIDE
- 1,3-Dibutyl-2-thiourea
- N-BUTYLTHIOUREA
- 2-Methyl-2-propanethiol
- Dibutyl sulfide
- L-BUTHIONINE-(S,R)-SULFOXIMINE
- L-BUTHIONINE
- FMOC-L-BUTHIONINESULFOXIMINE
- BOC-DL-BUTHIONINESULFOXIMINE
- FMOC-DL-BUTHIONINESULFOXIMINE