DL-BUTHIONINE-[S,R]-SULFOXIMINE

Product Name: DL-BUTHIONINE-[S,R]-SULFOXIMINE
CAS No.: 5072-26-4
Chemical Name: DL-BUTHIONINE-[S,R]-SULFOXIMINE
Synonyms: NSC 381100;butioninesulfoximine;buthioninesulfoximine;buthioninesulfoxamine;buthioninesulphoximine;DL-BUTHIONINE-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine,99%
CBNumber: CB4184630
Molecular Formula: C8H18N2O3S
Formula Weight: 222.31
MOL File: 5072-26-4.mol

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DL-BUTHIONINE-[S,R]-SULFOXIMINE Property

Melting point:: 215 °C (dec.)(lit.)
Boiling point:: 382.3±52.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL, clear, colorless
form: Fluffy Powder
color: White
Merck: 13,1520
BRN: 2367136
CAS DataBase Reference: 5072-26-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: EK7713435
F: 10
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 19176
Product name: DL-Buthionine-sulfoximine
Purity: ≥99.0% (TLC)
Packaging: 1g
Price: $331
Updated: 2024/03/01

Sigma-Aldrich

Product number: 19176
Product name: DL-Buthionine-sulfoximine
Purity: ≥99.0% (TLC)
Packaging: 5g
Price: $690
Updated: 2024/03/01

Cayman Chemical

Product number: 23691
Product name: D,L-Buthionine-(S,R)-sulfoximine
Purity: ≥98%
Packaging: 250mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23691
Product name: D,L-Buthionine-(S,R)-sulfoximine
Purity: ≥98%
Packaging: 500mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: B2640
Product name: DL-Buthionine-(S,R)-sulfoximine
Packaging: 500mg
Price: $138
Updated: 2024/03/01

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DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

A potent and specific inhibitor of alpha-glutamyl cysteine synthetase

Uses

DL-Buthionine-sulfoximine is suitable for use to:

examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
investigate the effect of BSO on development of bovine embryos
inhibit GSH in several studies
investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Uses

Biological tool for depletion of glutathione.

Definition

ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.

General Description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl 5-[3-(4,6-dimethoxy pyrimidyl-2-yl)ureido]methylpyrazolyl-4-carboxylic ester

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DL-BUTHIONINE-[S,R]-SULFOXIMINE Suppliers

Belgium 1 Canada 1 China 49 Germany 2 India 1 Japan 2 Switzerland 1 United Kingdom 6 United States 16 USA 1 Global 80

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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Shandong Xiya Chemical Co., Ltd.

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5072-26-4, DL-BUTHIONINE-[S,R]-SULFOXIMINERelated Search:

1-Dodecanethiol 4-Methyl-2-pentanone D,L-BUTHIONINE 4-(TERT-BUTYL)BENZENE-1-CARBOTHIOAMIDE Butylate Tetrabutylammonium hydrogen sulfate S-Butyrylthiocholine Iodide Terbufos TETRA-N-BUTYLTHIURAM DISULFIDE 1,3-Dibutyl-2-thiourea N-BUTYLTHIOUREA 2-Methyl-2-propanethiol Dibutyl sulfide L-BUTHIONINE-(S,R)-SULFOXIMINE L-BUTHIONINE FMOC-L-BUTHIONINESULFOXIMINE BOC-DL-BUTHIONINESULFOXIMINE FMOC-DL-BUTHIONINESULFOXIMINE

DL-BUTHIONINE (R,S)-SULFOXIMINE

DL-BUTHIONINE-[S,R]-SULFOXIMINE

DL-BUTHIONINE (S,R)-SULPHOXIME

DL-BUTHIONINE-SULFOXIMINE

2-amino-4-(s-butylsulfonimidoyl)-butanoicaci

2-amino-4-(s-butylsulfonimidoyl)butanoicacid

buthioninesulfoxamine

buthioninesulfoximine

buthioninesulphoximine

butioninesulfoximine

s-(3-amino-3-carboxypropyl)-s-butyl-sulfoximin

Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-.

NSC 381100

S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine

S-butyl-DL-homocysteine (S,R)-sulfoximine

2-Amino-4-(S-butylsulphonimidoyl)butanoic acid, S-(3-Amino-3-carboxypropyl)-S-butylsulphoximine

DL-Buthionine (S,R)-sulfoxiMine, 99% 500MG

2-Amino-4-(S-butylsulfonimidoyl)butyric acid

DL-Buthionine (S,R)-sulfoximine,99%

D,L-Buthionine-(S,R)-sulfoximine (Synonyms: Butionine sulfoximine)

D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)

2-Amino-4-(butylsulfonimidoyl)butanoic acid

BSO,DL Buthionine (S,R) sulfoximine,Buthionine sulfoximine,DLButhionine(S,R)sulfoximine,Inhibitor,inhibit,Ferroptosis

5072-26-4

C8H18N2O3S

CH3CH23SONHCH2CH2CHNH2CO2H

Biochemicals and Reagents

BioChemical

Fusarinine -C Ornithinesterase

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

D to K

Glutathione S-Transferase Agents

Sulfur & Selenium Compounds

D to

Drug and Xenobiotic Metabolism

Enzyme Inhibitors by Enzyme

Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism

Substrates, Inducers, Inhibitors