DL-BUTHIONINE-[S,R]-SULFOXIMINE
- Product Name
- DL-BUTHIONINE-[S,R]-SULFOXIMINE
- CAS No.
- 5072-26-4
- Chemical Name
- DL-BUTHIONINE-[S,R]-SULFOXIMINE
- Synonyms
- NSC 381100;butioninesulfoximine;buthioninesulfoximine;buthioninesulfoxamine;buthioninesulphoximine;DL-BUTHIONINE-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine,99%
- CBNumber
- CB4184630
- Molecular Formula
- C8H18N2O3S
- Formula Weight
- 222.31
- MOL File
- 5072-26-4.mol
DL-BUTHIONINE-[S,R]-SULFOXIMINE Property
- Melting point:
- 215 °C (dec.)(lit.)
- Boiling point:
- 382.3±52.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL, clear, colorless
- form
- Fluffy Powder
- color
- White
- Merck
- 13,1520
- BRN
- 2367136
- CAS DataBase Reference
- 5072-26-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19176
- Product name
- DL-Buthionine-sulfoximine
- Purity
- ≥99.0% (TLC)
- Packaging
- 1g
- Price
- $331
- Updated
- 2024/03/01
- Product number
- 19176
- Product name
- DL-Buthionine-sulfoximine
- Purity
- ≥99.0% (TLC)
- Packaging
- 5g
- Price
- $690
- Updated
- 2024/03/01
- Product number
- 23691
- Product name
- D,L-Buthionine-(S,R)-sulfoximine
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 23691
- Product name
- D,L-Buthionine-(S,R)-sulfoximine
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- B2640
- Product name
- DL-Buthionine-(S,R)-sulfoximine
- Packaging
- 500mg
- Price
- $138
- Updated
- 2024/03/01
DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Uses
DL-Buthionine-sulfoximine is suitable for use to:
- examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
- investigate the effect of BSO on development of bovine embryos
- inhibit GSH in several studies
- investigate the effect of GSH synthesis on oocyte maturation
Uses
Biological tool for depletion of glutathione.
Definition
ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
General Description
DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Biochem/physiol Actions
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).