ChemicalBook > CAS DataBase List > DL-BUTHIONINE-[S,R]-SULFOXIMINE

DL-BUTHIONINE-[S,R]-SULFOXIMINE

Product Name: DL-BUTHIONINE-[S,R]-SULFOXIMINE
CAS No.: 5072-26-4
Chemical Name: DL-BUTHIONINE-[S,R]-SULFOXIMINE
Synonyms: NSC 381100;butioninesulfoximine;buthioninesulfoximine;buthioninesulfoxamine;buthioninesulphoximine;DL-BUTHIONINE-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-Buthionine-sulfoximine
CBNumber: CB4184630
Molecular Formula: C8H18N2O3S
Formula Weight: 222.31
MOL File: 5072-26-4.mol

Less

DL-BUTHIONINE-[S,R]-SULFOXIMINE Property

Melting point:: 215 °C (dec.)(lit.)
Boiling point:: 382.3±52.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL, clear, colorless
form: Fluffy Powder
color: White
biological source: synthetic (organic)
Water Solubility: water: 50mg/mL, clear to very slightly hazy, colorless to yellow
Merck: 13,1520
BRN: 2367136
CAS DataBase Reference: 5072-26-4(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: EK7713435
F: 10
HS Code: 29309090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 19176
Product name: DL-Buthionine-sulfoximine
Purity: ≥99.0% (TLC)
Packaging: 1g
Price: $340
Updated: 2025/07/31

Sigma-Aldrich

Product number: 19176
Product name: DL-Buthionine-sulfoximine
Purity: ≥99.0% (TLC)
Packaging: 5g
Price: $1180
Updated: 2025/07/31

Cayman Chemical

Product number: 23691
Product name: D,L-Buthionine-(S,R)-sulfoximine
Purity: ≥98%
Packaging: 250mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23691
Product name: D,L-Buthionine-(S,R)-sulfoximine
Purity: ≥98%
Packaging: 500mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: B2640
Product name: DL-Buthionine-(S,R)-sulfoximine
Packaging: 500mg
Price: $142
Updated: 2025/07/31

Less

DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

A potent and specific inhibitor of alpha-glutamyl cysteine synthetase

Uses

DL-Buthionine-sulfoximine is suitable for use to:

examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
investigate the effect of BSO on development of bovine embryos
inhibit GSH in several studies
investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Uses

Biological tool for depletion of glutathione.

Definition

ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.

General Description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl 5-[3-(4,6-dimethoxy pyrimidyl-2-yl)ureido]methylpyrazolyl-4-carboxylic ester

Less

DL-BUTHIONINE-[S,R]-SULFOXIMINE Suppliers

Belgium 1 Canada 1 China 76 Germany 2 India 1 Japan 2 Switzerland 1 United Kingdom 6 United States 18 USA 1 Global 109

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 9941
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 +86-17392581500
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 3987
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Hubei yongkuo Technology Co., Ltd

Tel: 027-027-59223108 15972152991
Fax: 027-59223108
Email: 1248580099@qq.com
Country: China
ProdList: 9953
Advantage: 58

Hubei Guangao Biotechnology Co., Ltd

Tel: 027-02702759223056 18162699093
Fax: 027-59223056
Email: 1208480011@qq.com
Country: China
ProdList: 9875
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Taopu Industrial Co., LTD

Tel: 159-00573766 18018507602
Email: 394643792@qq.com
Country: China
ProdList: 4328
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

JiangSu Star Science Co.,Ltd

Tel: 400-605-7200 15335295587
Email: 3941881028@qq.com
Country: China
ProdList: 3760
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Shanghai Yingxin laboratory equipment Co., Ltd

Tel: 021-021-59178156 15300768757
Email: 359382369@qq.com
Country: China
ProdList: 10674
Advantage: 58

Shanghai Guchen Biotechnology Co., LTD

Tel: 021-34675735 19147740836
Email: 1986399151@qq.com
Country: China
ProdList: 9844
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Yeasen Biotechnology (Shanghai) Co Ltd

Tel: 400-6111-883 13121892008
Email: marketing@yeasen.com
Country: China
ProdList: 6173
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Biosharp

Tel: 400-600-4213
Email: info@labgic.com
Country: China
ProdList: 6191
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

5072-26-4, DL-BUTHIONINE-[S,R]-SULFOXIMINERelated Search:

1-Dodecanethiol 4-Methyl-2-pentanone D,L-BUTHIONINE 4-(TERT-BUTYL)BENZENE-1-CARBOTHIOAMIDE Tetrabutylammonium hydrogen sulfate S-Butyrylthiocholine Iodide Terbufos TETRA-N-BUTYLTHIURAM DISULFIDE 1,3-Dibutyl-2-thiourea N-BUTYLTHIOUREA 2-Methyl-2-propanethiol Dibutyl sulfide L-BUTHIONINE-(S,R)-SULFOXIMINE Butylate L-BUTHIONINE FMOC-L-BUTHIONINESULFOXIMINE BOC-DL-BUTHIONINESULFOXIMINE FMOC-DL-BUTHIONINESULFOXIMINE

DL-BUTHIONINE (R,S)-SULFOXIMINE

DL-BUTHIONINE-[S,R]-SULFOXIMINE

DL-BUTHIONINE (S,R)-SULPHOXIME

DL-BUTHIONINE-SULFOXIMINE

2-amino-4-(s-butylsulfonimidoyl)-butanoicaci

2-amino-4-(s-butylsulfonimidoyl)butanoicacid

buthioninesulfoxamine

buthioninesulfoximine

buthioninesulphoximine

butioninesulfoximine

s-(3-amino-3-carboxypropyl)-s-butyl-sulfoximin

Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-.

NSC 381100

S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine

S-butyl-DL-homocysteine (S,R)-sulfoximine

2-Amino-4-(S-butylsulphonimidoyl)butanoic acid, S-(3-Amino-3-carboxypropyl)-S-butylsulphoximine

DL-Buthionine (S,R)-sulfoxiMine, 99% 500MG

2-Amino-4-(S-butylsulfonimidoyl)butyric acid

DL-Buthionine (S,R)-sulfoximine,99%

D,L-Buthionine-(S,R)-sulfoximine (Synonyms: Butionine sulfoximine)

D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)

2-Amino-4-(butylsulfonimidoyl)butanoic acid

BSO,DL Buthionine (S,R) sulfoximine,Buthionine sulfoximine,DLButhionine(S,R)sulfoximine,Inhibitor,inhibit,Ferroptosis

D,L-Buthionine-(S,R)-sulfoximine, gamma-glutamyl cysteine synthase inhibitor

<sc>DL</sc>-Buthionine-sulfoximine

<sc>DL</sc>-Buthionine-(<i>S</i>,<i>R</i>)-sulfoximine

DL-Buthionine-(S,R)-sulfoximine,5072-26-4

5072-26-4

C8H18N2O3S

CH3CH23SONHCH2CH2CHNH2CO2H

Biochemicals and Reagents

BioChemical

Fusarinine -C Ornithinesterase

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

D to K

Glutathione S-Transferase Agents

Sulfur & Selenium Compounds

D to

Drug and Xenobiotic Metabolism

Enzyme Inhibitors by Enzyme

Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism

Substrates, Inducers, Inhibitors