ChemicalBook > CAS DataBase List > DL-BUTHIONINE-[S,R]-SULFOXIMINE

DL-BUTHIONINE-[S,R]-SULFOXIMINE

Product Name
DL-BUTHIONINE-[S,R]-SULFOXIMINE
CAS No.
5072-26-4
Chemical Name
DL-BUTHIONINE-[S,R]-SULFOXIMINE
Synonyms
NSC 381100;butioninesulfoximine;buthioninesulfoximine;buthioninesulfoxamine;buthioninesulphoximine;DL-BUTHIONINE-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine,99%
CBNumber
CB4184630
Molecular Formula
C8H18N2O3S
Formula Weight
222.31
MOL File
5072-26-4.mol
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DL-BUTHIONINE-[S,R]-SULFOXIMINE Property

Melting point:
215 °C (dec.)(lit.)
Boiling point:
382.3±52.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
Fluffy Powder
color 
White
Merck 
13,1520
BRN 
2367136
CAS DataBase Reference
5072-26-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
EK7713435
10
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
19176
Product name
DL-Buthionine-sulfoximine
Purity
≥99.0% (TLC)
Packaging
1g
Price
$331
Updated
2024/03/01
Sigma-Aldrich
Product number
19176
Product name
DL-Buthionine-sulfoximine
Purity
≥99.0% (TLC)
Packaging
5g
Price
$690
Updated
2024/03/01
Cayman Chemical
Product number
23691
Product name
D,L-Buthionine-(S,R)-sulfoximine
Purity
≥98%
Packaging
250mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
23691
Product name
D,L-Buthionine-(S,R)-sulfoximine
Purity
≥98%
Packaging
500mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
B2640
Product name
DL-Buthionine-(S,R)-sulfoximine
Packaging
500mg
Price
$138
Updated
2024/03/01
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DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

A potent and specific inhibitor of alpha-glutamyl cysteine synthetase

Uses

DL-Buthionine-sulfoximine is suitable for use to:

  • examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
  • investigate the effect of BSO on development of bovine embryos
  • inhibit GSH in several studies
  • investigate the effect of GSH synthesis on oocyte maturation
It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Uses

Biological tool for depletion of glutathione.

Definition

ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.

General Description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-BUTHIONINE-[S,R]-SULFOXIMINE Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169109
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86-21-61259102
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market03@meryer.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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Thermo Fisher Scientific
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Beijing innoChem Science & Technology Co.,Ltd.
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9ding chemical ( Shanghai) Limited
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Shanghai Macklin Biochemical Co.,Ltd.
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15221275939 15221275939
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021-50706099
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shenlinxing@macklin.cn
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Shandong Xiya Chemical Co., Ltd.
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4009903999 13395398332
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0539-6365991
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sales@xiyashiji.com
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China
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20806
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5072-26-4, DL-BUTHIONINE-[S,R]-SULFOXIMINERelated Search:


  • DL-BUTHIONINE (R,S)-SULFOXIMINE
  • DL-BUTHIONINE-[S,R]-SULFOXIMINE
  • DL-BUTHIONINE (S,R)-SULPHOXIME
  • DL-BUTHIONINE-SULFOXIMINE
  • 2-amino-4-(s-butylsulfonimidoyl)-butanoicaci
  • 2-amino-4-(s-butylsulfonimidoyl)butanoicacid
  • buthioninesulfoxamine
  • buthioninesulfoximine
  • buthioninesulphoximine
  • butioninesulfoximine
  • s-(3-amino-3-carboxypropyl)-s-butyl-sulfoximin
  • Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-.
  • NSC 381100
  • S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine
  • S-butyl-DL-homocysteine (S,R)-sulfoximine
  • 2-Amino-4-(S-butylsulphonimidoyl)butanoic acid, S-(3-Amino-3-carboxypropyl)-S-butylsulphoximine
  • DL-Buthionine (S,R)-sulfoxiMine, 99% 500MG
  • 2-Amino-4-(S-butylsulfonimidoyl)butyric acid
  • DL-Buthionine (S,R)-sulfoximine,99%
  • D,L-Buthionine-(S,R)-sulfoximine (Synonyms: Butionine sulfoximine)
  • D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)
  • 2-Amino-4-(butylsulfonimidoyl)butanoic acid
  • BSO,DL Buthionine (S,R) sulfoximine,Buthionine sulfoximine,DLButhionine(S,R)sulfoximine,Inhibitor,inhibit,Ferroptosis
  • 5072-26-4
  • C8H18N2O3S
  • CH3CH23SONHCH2CH2CHNH2CO2H
  • Biochemicals and Reagents
  • BioChemical
  • Fusarinine -C Ornithinesterase
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • D to K
  • Glutathione S-Transferase Agents
  • Sulfur & Selenium Compounds
  • D to
  • Drug and Xenobiotic Metabolism
  • Enzyme Inhibitors by Enzyme
  • Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism
  • Substrates, Inducers, Inhibitors