LEUROSINE
LEUROSINE Basic information
- Product Name:
- LEUROSINE
- Synonyms:
-
- 4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin
- 4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin
- amotin
- LEUROSINE
- Vincristine EP Impurity F
- Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
- Vincristine EP Impurity F (Leurosine)
- nsc-528004
- CAS:
- 23360-92-1
- MF:
- C46H56N4O9
- MW:
- 808.97
- Mol File:
- 23360-92-1.mol
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LEUROSINE Chemical Properties
- Melting point:
- 202-205℃
- Density
- 1.39
- pka
- 11.36±0.60(Predicted)
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Safety Information
- RIDADR
- 1544
- HazardClass
- 6.1(a)
- PackingGroup
- II
- Hazardous Substances Data
- 23360-92-1(Hazardous Substances Data)
- Toxicity
- dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.
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LEUROSINE Usage And Synthesis
Description
Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).
Uses
Antineoplastic.
Uses
Vinleurosine is an antitumor compound derived from Vinca Rosea.
Definition
ChEBI: Leurosine is a vinca alkaloid.
References
Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)
LEUROSINESupplier
ChemStrong Scientific Co.,Ltd
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- 0755-0755-66853366 13670046396
- sales@chem-strong.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Chengdu HuaXia Chemical Reagent Co. Ltd
- Tel
- 400-1166-196 13458535857
- cdhxsj@163.com
Shanghai Kewel Chemical Co., Ltd.
- Tel
- 021-64609169 18901607656
- greensnown@163.com
Lianyungang TengFa Biological Technology Co. Ltd
- Tel
- 0518-85475186 18705131893
- wang666xt@163.com
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LEUROSINE(23360-92-1)Related Product Information
- VincristineM1
- 4'-Deoxy Vincristine
- N-Desmethylvinblastine
- Vinorelbine EP Impurity G
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2-oxido-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
- 4-Desacetyl Vinblastine
- 3',4'-Anhydrovinblastine
- Vinorelbine EP Impurity H
- Cophylline
- desacetylnavelbine
- Vinorelbine EP Impurity F
- VINBLASTINE
- (2R,3R)-3-AMINO-2-HYDROXYHEXANOIC ACID
- LEUROSINE
- (R)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE
- 3-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID
- (R)-3-AMINO-4-(4-METHOXYPHENYL)BUTANOIC ACID
- (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE