BRUCINE Chemical Properties

Melting point:

175-178 °C (dec.)(lit.)

optical activity

[α]20/D 67°, c = 1.3 in ethanol

Water Solubility 

Soluble in methanol. Partially soluble Miscible with water.

CAS DataBase Reference

5892-11-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

T+

Risk Statements 

26/28-52/53-36/37/38-26/27/28

Safety Statements 

13-45-61-36/37-28

RIDADR 

UN 1570 6.1/PG 1

WGK Germany 

3

RTECS 

EH8925000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

I

MSDS

• Language:English Provider:SigmaAldrich

BRUCINE Usage And Synthesis

Uses

Resolving agentBrucine dihydrate is used as a resolving agent for chiral acids.

Purification Methods

Crystallise brucine once from water or aqueous Me2CO (as the tetrahydrate), then suspend it in CHCl3 and shake with anhydrous Na2SO4 (to dehydrate the brucine, which then dissolves). Precipitate it by pouring the solution into a large bulk of dry pet ether (b 40-60o), filter and heat to 120o in a high vacuum [Turner J Chem Soc 842 1951]. The tetrahydrate crystallises from a mixture of EtOH and H2O as colourless elongated needles [Eeles Acta Cryst 6 809 1953, Beilstein 27 III/IV 7875.] VERY POISONOUS