FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride Chemical Properties

Melting point:

144-146 °C(Solv: acetone (67-64-1))

storage temp. 

Desiccate at RT

solubility 

H2O: soluble >10mg/mL

form 

powder

color 

off-white

optical activity

[α]27/D 7.2°, c = 0.3 in methanol(lit.)

Water Solubility 

Soluble to 100 mM in water

Safety Information

WGK Germany 

3

RTECS 

CV2450000

FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride Usage And Synthesis

Uses

Dopamine receptor antagonist

Uses

S-(?)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.

Biological Activity

Selective dopamine D 2 /D 3 receptor antagonist (K i values are 0.50 and 0.16 nM respectively). Antipsychotic.

Biochem/physiol Actions

Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2?receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.

storage

room temperature (desiccate)

FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride(97612-24-3)Related Product Information

• Etidronate disodium
• S(-)-ETICLOPRIDE HYDROCHLORIDE