4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID Chemical Properties

Boiling point:

707.3±70.0 °C(Predicted)

Density 

1.320±0.06 g/cm3(Predicted)

pka

1.04±0.36(Predicted)

4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID Usage And Synthesis

Uses

A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats[1].

IC 50

AT1 Receptor: 9.64 (pA2)

References

[1] Hancock AA, et al. Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors. Life Sci. 1993;53(11):929-37. DOI:10.1016/0024-3205(93)90445-9

4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID(141872-46-0)Related Product Information

• 5-BIPHENYL-2-YL-2H-TETRAZOLE
• 4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID
• 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE