N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE
N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE Basic information
- Product Name:
- N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE
- Synonyms:
-
- N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE
- TOSLAB-BB TOS-BB-1282
- 2-(5,6-dimethyl-1H-benzimidazol-2-yl)guanidine
- Guanidine, (5,6-dimethyl-1H-benzimidazol-2-yl)- (9CI)
- DHFR-IN-19
- CAS:
- 41927-06-4
- MF:
- C10H13N5
- MW:
- 203.24
- Mol File:
- 41927-06-4.mol
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N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE Usage And Synthesis
Uses
DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with Ki of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC50 of 14.5 μM[1].
References
[1] Francesconi V, et al., Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents. ACS Infect Dis. 2024 Jul 2. DOI:10.1021/acsinfecdis.4c00113