CALMIDAZOLIUM CHLORIDE Chemical Properties

Melting point:

172-176 °C

storage temp. 

2-8°C

solubility 

Soluble to 100 mM in DMSO and to 100 mM in ethanol

form 

solid

color 

white

Water Solubility 

Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water.

BRN 

6470244

Safety Information

Safety Statements 

22-24/25

RIDADR 

UN 2811 6.1 / PGII

WGK Germany 

3

RTECS 

Gk2402500

F 

3-8-10

HS Code 

29332990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

CALMIDAZOLIUM CHLORIDE Usage And Synthesis

Chemical Properties

white to off-white powder

Uses

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

General Description

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

Biological Activity

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Biochem/physiol Actions

Inhibitor of calmodulin-regulated enzymes. It is also believed to directly block calcium channels in smooth muscle cells.

storage

+4°C

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