2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL Chemical Properties

Boiling point:

125-126 °C (7 mmHg)

Density 

1.29

refractive index 

1.559-1.561

Flash point:

108 °C

storage temp. 

Inert atmosphere,Room Temperature

pka

13.67±0.20(Predicted)

form 

Liquid

Specific Gravity

1.293

color 

Clear colorless

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

HS Code 

29062900

MSDS

• Language:English Provider:ACROS

2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL Usage And Synthesis

Chemical Properties

clear colorless liquid

Synthesis

Sodium borohydride (0.33 g) was slowly added to a methanolic solution (15 ml) of 2,4-dichloroacetophenone (3.0 g) under cooling conditions in an ice bath. The reaction mixture was stirred at room temperature for 30 min before the reaction was terminated by the addition of water (30 ml) followed by extraction with ethyl acetate (30 ml x 2). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate-hexane (2:1, v/v) as eluent to afford 1-(2,4-dichlorophenyl)ethanol as a colorless oil (3.00 g, 99% yield).1H-NMR (300 MHz, CDCl3) δ: 1.47 (3H, d, J=6.2 Hz), 1.94 (1H, d, J=3.6 Hz ), 5.25 (1H, qd, J=6.3,3.9Hz), 7.23-7.37 (2H, m), 7.55 (1H, d, J=8.0Hz).

References

[1] Patent: EP1829863, 2007, A1
[2] Patent: WO2006/57448, 2006, A1. Location in patent: Page/Page column 116-117
[3] Zhurnal Obshchei Khimii, 1952, vol. 22, p. 489; engl. Ausg. S. 551
[4] Journal of the Chemical Society, Dalton Transactions, 2001, # 20, p. 2989 - 2995
[5] Advanced Synthesis and Catalysis, 2010, vol. 352, # 10, p. 1779 - 1783

2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL(1475-13-4)Related Product Information

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• 2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL
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