(+/-)5(6)-EPOXY-8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID, METHYL ESTER Chemical Properties

solubility 

DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:1): 500 μg/ml

(+/-)5(6)-EPOXY-8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID, METHYL ESTER Usage And Synthesis

Description

(±)5(6)-EpETE methyl ester is a derivative of 5(6)-EpETE which is stable enough to ship and handle routinely.(±) 5(6)-EpETE methyl ester is a chemically less reactive derivative of 5(6)-EpETE. The active free acid can be generated from the methyl ester by careful base hydrolysis. Epoxy eicosatetraenoic acids (EpETEs) are the epoxygenase metabolites of EPA. A number of vicinal diol metabolites of EpETEs have been detected in the plasma of patients on marine oil dietary supplementation, while in subjects on a typical western diet these compounds are generally not detected.¹ The specific biologic activity of 5(6)-EpETE and its methyl ester have not been documented.

References

1. Knapp, H.R., Miller, A.J., and Lawson, J.A. Urinary excretion of diols derived from eicosapentaenoic acid during N-3 fatty acid ingestion Prostaglandins 42,47-53(1991).

(+/-)5(6)-EPOXY-8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID, METHYL ESTER(127716-49-8)Related Product Information

• (+/-)5(6)-EPOXY-8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID, METHYL ESTER
• 8Z,11Z,14Z,17Z-EICOSATETRAENOIC ACID