Basic information Safety Supplier Related

4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE

Basic information Safety Supplier Related

4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE Basic information

Product Name:
4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE
Synonyms:
  • 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrilehydrochloride
  • BX 513 HCL
  • 4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE
  • BX 513 HYDROCHLORIDE
  • BX 513
  • BX513
  • BX513;BX 513
  • 1-Piperidinepentanenitrile, 4-(4-chlorophenyl)-4-hydroxy-α,α-diphenyl-
CAS:
193542-65-3
MF:
C28H29ClN2O
MW:
445
Mol File:
193542-65-3.mol
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4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE Chemical Properties

storage temp. 
Desiccate at +4°C
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4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE Usage And Synthesis

Biological Activity

Selective CCR1 receptor antagonist (K i values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1 α -induced intracellular calcium mobilization (IC 50 = 2.5 μ M). Also a full inverse agonist at US28, a? HCMV-encoded chemokine receptor.

4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDESupplier

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