4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE
4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE Basic information
- Product Name:
- 4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE
- Synonyms:
-
- 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrilehydrochloride
- BX 513 HCL
- 4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE
- BX 513 HYDROCHLORIDE
- BX 513
- BX513
- BX513;BX 513
- 1-Piperidinepentanenitrile, 4-(4-chlorophenyl)-4-hydroxy-α,α-diphenyl-
- CAS:
- 193542-65-3
- MF:
- C28H29ClN2O
- MW:
- 445
- Mol File:
- 193542-65-3.mol
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4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE Chemical Properties
- storage temp.
- Desiccate at +4°C
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4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE Usage And Synthesis
Biological Activity
Selective CCR1 receptor antagonist (K i values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1 α -induced intracellular calcium mobilization (IC 50 = 2.5 μ M). Also a full inverse agonist at US28, a? HCMV-encoded chemokine receptor.
4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDESupplier
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