4-(4-Chlorophenyl)piperidine Chemical Properties

Melting point:

0°C

Boiling point:

0°C

Density 

1.095±0.06 g/cm3(Predicted)

Flash point:

0°C

storage temp. 

2-8°C(protect from light)

solubility 

soluble in Methanol

form 

powder to crystal

pka

10.14±0.10(Predicted)

color 

White to Orange to Green

CAS DataBase Reference

26905-02-2

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

HS Code 

2933399990

4-(4-Chlorophenyl)piperidine Usage And Synthesis

Synthesis

To a solution of 5.0 g (21.7 mmol) of 4-(4-chloro-phenyl)-1,2,3,6-tetrahydro-pyridine in 20 mL methanol are added 500 mg Pd/C. The reaction mixture is stirred for 7 h at ambient temperature and 10 psi hydrogen. After the catalyst is separated, the solvent is eliminated using the rotary evaporator. Further purification is carried out by column chromatography on silica gel (eluant: dichloromethane/methanol/ammonia=5:4.9:0.1) to afford 4-(4-Chlorophenyl)piperidine.

References

[1] Patent: WO2014/8197, 2014, A1. Location in patent: Page/Page column 113
[2] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 127; 128
[3] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 10, p. 1731 - 1735

4-(4-Chlorophenyl)piperidine(26905-02-2)Related Product Information

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