NS 1738 Chemical Properties

Boiling point:

344.1±42.0 °C(Predicted)

Density 

1.617±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

White crystalline solid.

pka

8.08±0.13(Predicted)

color 

Off-White to Light Grey

NS 1738 Usage And Synthesis

Description

NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC₅₀ = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.

Uses

NS 1738 is a selective a7 nAchR allosteric modulator.

Biological Activity

Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .

storage

Store at RT

NS 1738(501684-93-1)Related Product Information

• NS1652
• NS1643
• NS-6180
• NS 1738