3-AMINOPROPIONITRILE FUMARATE Chemical Properties

Melting point:

177 °C (dec.)(lit.)

storage temp. 

-20°C

form 

Crystalline Powder

color 

White

Water Solubility 

almost transparency

BRN 

3573532

CAS DataBase Reference

2079-89-2(CAS DataBase Reference)

EPA Substance Registry System

Propanenitrile, 3-amino-, (2E)-2-butenedioate (2:1) (2079-89-2)

Safety Information

Hazard Codes 

T

Risk Statements 

61

Safety Statements 

53-45

WGK Germany 

3

RTECS 

UG0700000

TSCA 

Yes

HS Code 

29269095

Toxicity

LDLo orl-rat: 800 mg/kg TJADAB 5,33,72

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-AMINOPROPIONITRILE FUMARATE Usage And Synthesis

Chemical Properties

WHITE CRYSTALLINE POWDER

Uses

3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:

• to inhibit collagen cross-linking during microtissue formation and culture
• in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay
• in lysyl oxidase (LOX) activity assay
• to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids

Definition

ChEBI: A fumarate salt prepared from beta-aminopropionitrile by reaction of one molecule of fumaric acid for every two molecules of beta-aminopropionitrile.

Biochem/physiol Actions

3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO, and CN-. See also NITRILES.

3-AMINOPROPIONITRILE FUMARATE(2079-89-2)Related Product Information

• 3,3'-IMINODIPROPIONITRILE
• 3-Aminopropanol
• Amino resin
• Propionitrile
• 3-Aminopropionitrile
• Fumaric acid
• 3-AMINOPROPIONITRILE FUMARATE