methyl-2-amino-2-cyclopropyla cetate hydrochloride Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

form 

Solid

color 

White to light brown

Safety Information

HazardClass 

IRRITANT

HS Code 

2922498590

methyl-2-amino-2-cyclopropyla cetate hydrochloride Usage And Synthesis

Uses

Methyl 2-amino-2-cyclopropylacetate hydrochloride is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

Synthesis

General procedure for the synthesis of methyl 2-amino-2-cyclopropylacetate hydrochloride from DL-cyclopropylglycine: Thionyl chloride (1.3 g, 0.8 mL, 11 mmol) was added slowly and dropwise to a methanol (4.3 mL) solution of DL-cyclopropylglycine (0.50 g, 4.3 mmol) that was cooled to 0°C. The reaction mixture was stirred for 10 minutes and then gradually warmed to room temperature. The reaction mixture was stirred at 0°C for 10 min and then gradually warmed to room temperature. Stirring was continued at room temperature overnight. Upon completion of the reaction, the mixture was concentrated and dried under pressure of 0.5 mmHg at room temperature to afford methyl 2-amino-2-cyclopropylacetate hydrochloride (0.60 g, 85% yield) as a white solid. The product was characterized by 1H NMR (DMSO-d6): δ 0.51-0.69, 1.05-1.17, 3.36-3.39, 3.75, 8.69.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

methyl-2-amino-2-cyclopropyla cetate hydrochloride(535936-86-8)Related Product Information

• CYCLOBUTYLHYDRAZINE DIHYDROCHLORIDE
• CYCLOPROPYL 2,4-DIFLUOROPHENYL KETONE
• Cyclopropyl(4,6-dichloropyridin-3-yl)methanone
• FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE
• 2,9-Decanedione
• Cyclopropyl(4-pyridyl) ketone
• Amino-cyclopropyl-acetic acid methyl ester
• Methylphenidate hydrochloride