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5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate

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5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate Basic information

Product Name:
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate
Synonyms:
  • 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate
  • 2',5-D733ichloro-4'-nitrosalicylanilide Hydrate
  • 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzaMide Hydrate
  • Cestocide
  • N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylaMide Hydrate
  • Zestocarp
  • Glumetinib Impurity 16
CAS:
73360-56-2
MF:
C13H8Cl2N2O4.H2O
MW:
345.14
Product Categories:
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
73360-56-2.mol
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5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate Chemical Properties

Melting point:
224-229℃
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
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Safety Information

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
VN8400000
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5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate Usage And Synthesis

Uses

Niclosamide Monohydrate can be used as oral therapeutics.

Uses

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate is used as an anthelmintic drug (Cestodes).

in vivo

Niclosamide monohydrate (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].

Animal Model:Nu+/Nu+ mice injected with NCI-H295R cells[3]
Dosage:100 mg/kg, 200 mg/kg
Administration:Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
Result:Showed a 60%-80% inhibition in tumor growth, as compared to the control group.

IC 50

STAT3: 0.25 μM (IC50, in HeLa cells)

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