Acetyl Tetrapeptide-5 Chemical Properties

Boiling point:

1237.3±65.0 °C(Predicted)

Density 

1.443

storage temp. 

2-8°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

pka

2.76±0.10(Predicted)

color 

White to off-white

InChI

InChI=1/C20H28N8O7/c1-11(30)23-3-2-17(31)26-14(4-12-6-21-9-24-12)18(32)28-16(8-29)19(33)27-15(20(34)35)5-13-7-22-10-25-13/h6-7,9-10,12-16,29H,2-5,8H2,1H3,(H,23,30)(H,26,31)(H,27,33)(H,28,32)(H,34,35)/t12?,13?,14-,15-,16-/s3

InChIKey

RIUMNDWYYDHBFO-UDJPXWLSNA-N

SMILES

C(O)(=O)[C@H](CC1N=CN=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1N=CN=C1)NC(=O)CCNC(C)=O |&1:3,13,19,r|

Acetyl Tetrapeptide-5 Usage And Synthesis

Chemical Properties

Acetyl Tetrapeptide-5 is a white to cream coloured powder. The active ingredient is used to treat lachrymal sacs and dark circles under the eyes. It stimulates cell metabolism, improves skin elasticity, reduces puffiness and water retention in the eye area and makes the skin supple.

Characteristics

Acetyl tetrapeptide-5 inhibits collagen glycation avoiding skin losing elasticity and subsequent eyebags formation .
Acetyl tetrapeptide-5 prevents liquid accumulation in eyebags .
Acetyl tetrapeptide-5 shows a slight lightening effect which decreases dark circles under the eyes Use level: 0.01 %, maximum 0.1 % (water soluble)

Uses

Acetyl tetrapeptide-5 is known as eye peptide and eye silk peptide. The molecular weight of acetyltetrapeptide-5 is 492.5 and the amino acid sequence is Ac- βAla-His-Ser-His-OH, the molecular formula is C20H28N8O7. The influence of saccharification in the body and the increase of ocular vascular osmotic pressure will make the eye skin form dark circles and edema. Some studies have proved that acetyltetrapeptide-5 can reduce edema by changing the microcirculation of regional skin and the osmotic pressure of liquid, so as to effectively eliminate edema, eye bags and dark circles.

Definition

Acetyl Tetrapeptide-5 is a synthetic peptide that has calming, smoothing, hydrating, and firmness-enhancing benefits when applied to skin. Its calming properties are believed to reduce undereye puffiness due to fluid accumulation, such as from allergies (which is not the same as undereye bags that occur from fat pads beneath the skin slipping out of place).

Application

Acetyl tetrapeptisde-5 is a known humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity and overall smoothness.

benefits

Acetyl tetrapeptide-5 is an acetyl oligopeptide whose role is to inhibit collagen glycation and increase vascular permeability in a dose-dependent manner. This prevents liquid accumulation under the eyes and decreases eye puffiness, as well as improving skin elasticity. Two studies showed that acetyl tetrapeptide-5 reduced under-eye puffiness and discoloration.

Safety

Some humectants may be irritants at extremely high concentrations, but acetyl tetrapeptide-5 is generally considered non-hazardous to the body and the environment by the cosmetics database.

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