ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyridazine compounds > 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Basic information
- Product Name:
- 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
- Synonyms:
-
- 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
- 4,5-dichloro-2-(3-Methylphenyl)-2,3-dihydropyridazin-3-one
- 4,5-Dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone
- LCS-1
- SOD1 Inhibitor, LCS-1
- 4,5-dichloro-2-(3-methylphenyl)pyridazin-3-one
- LCS-1 (LCS1)
- SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem
- CAS:
- 41931-13-9
- MF:
- C11H8Cl2N2O
- MW:
- 255.1
- Mol File:
- 41931-13-9.mol
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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Chemical Properties
- Melting point:
- 117 °C
- Boiling point:
- 339.6±52.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL (clear solutikon, warmed)
- form
- White solid
- pka
- -3.29±0.60(Predicted)
- color
- white to beige
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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Usage And Synthesis
Uses
LCS 1 is an inhibitor of Superoxide Dismutase 1 (SOD1).
Biochem/physiol Actions
LCS-1 is an inhibitor of superoxide dismutase (SOD1). LCS-1 inhibits the proliferation of lung adendocarcinoma cell lines.
in vivo
LCS-1 (20 mg/kg; i.p. every other day for 14 days) inhibits MM growth and prolongs host survival in MM.1S-bearing mice[3].
| Animal Model: | 5-week-old female CB17 SCID mice (MM.1S tumors volume=100 mm3)[3] |
| Dosage: | 20 mg/kg (diluted in saline) |
| Administration: | Intraperitoneal injections; treated on an every other day schedule for 14 days |
| Result: | Inhibited MM growth and prolongs host survival. |
IC 50
SOD1: 1.07 μM (IC50)
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-oneSupplier
Nanjing Norris-Pharm Technology Co., Ltd
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Shanghai Yolne Chemical Co., Ltd.
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Sigma-Aldrich
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