4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one CAS#: 41931-13-9

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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one

Basic information Safety Supplier Related

4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Basic information

Product Name:

4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one

Synonyms:

4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
4,5-dichloro-2-(3-Methylphenyl)-2,3-dihydropyridazin-3-one
4,5-Dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone
LCS-1
SOD1 Inhibitor, LCS-1
4,5-dichloro-2-(3-methylphenyl)pyridazin-3-one
LCS-1 (LCS1)
SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem

CAS:

41931-13-9

MF:

C11H8Cl2N2O

MW:

255.1

Mol File:

41931-13-9.mol

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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Chemical Properties

Melting point:: 117 °C
Boiling point:: 339.6±52.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL (clear solutikon, warmed)
pka: -3.29±0.60(Predicted)
form: White solid
color: white to beige
InChI: 1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3
InChIKey: SYUPLLHVMCLXEM-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2

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Safety Information

Hazard Codes: T,Xi
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral
Eye Irrit. 2

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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Usage And Synthesis

Uses

LCS 1 is an inhibitor of Superoxide Dismutase 1 (SOD1).

Biochem/physiol Actions

LCS-1 is an inhibitor of superoxide dismutase (SOD1). LCS-1 inhibits the proliferation of lung adendocarcinoma cell lines.

in vivo

LCS-1 (20 mg/kg; i.p. every other day for 14 days) inhibits MM growth and prolongs host survival in MM.1S-bearing mice^[3].

Animal Model:	5-week-old female CB17 SCID mice (MM.1S tumors volume=100 mm³)^[3]
Dosage:	20 mg/kg (diluted in saline)
Administration:	Intraperitoneal injections; treated on an every other day schedule for 14 days
Result:	Inhibited MM growth and prolongs host survival.

IC 50

SOD1: 1.07 μM (IC₅₀)

4,5-Dichloro-2-m-tolylpyridazin-3(2H)-oneSupplier

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Email: sales@norris-pharm.com

SynAsst Chemical.

Tel: 021-60343070

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Email: 934678158@qq.com

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Email: product02@bidepharm.com

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com

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