AVE8062A Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: soluble; Ethanol: soluble

form 

powder

color 

white to beige

Safety Information

RTECS 

TX1404540

AVE8062A Usage And Synthesis

General Description

Ombrabulin is a member of the combretastatin A-4 compound class and is a tubulin-depolymerising tumour vascular-disrupting compound.

Biochem/physiol Actions

Ombrabulin is a synthetic water-soluble combretastatin analog vascular disrupting agent. Ombrabulin is a tubulin polymerization inhibitor. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.

AVE8062A(253426-24-3)Related Product Information

• OMecaMtiv Mecarbil
• GSK-2126458
• Olmutinib
• Ombrabulin