WYE 354-d3
WYE 354-d3 Basic information
- Product Name:
- WYE 354-d3
- Synonyms:
-
- WYE 354-d3
- 4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
- CAS:
- 1794791-66-4
- MF:
- C24H29N7O5
- MW:
- 495.54
- Product Categories:
-
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Isotope Labelled Compounds
- Pharmaceuticals
- Protein Kinase Inhibitors and Activators
- Mol File:
- 1794791-66-4.mol
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WYE 354-d3 Usage And Synthesis
Uses
A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.