Basic information Safety Supplier Related

SUMATRIPTAN-D6 HEMISUCCINATE

Basic information Safety Supplier Related

SUMATRIPTAN-D6 HEMISUCCINATE Basic information

Product Name:
SUMATRIPTAN-D6 HEMISUCCINATE
Synonyms:
  • SUMATRIPTAN-D6 HEMISUCCINATE
  • 3-[2-[di(methyl-d3)amino]ethyl]-N-methyl-1H-indole-5-methanesulfonamide, butanedioic acid (2:1)
CAS:
1397195-80-0
MF:
C18H27N3O6S
MW:
413.49
Mol File:
1397195-80-0.mol
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SUMATRIPTAN-D6 HEMISUCCINATE Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
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SUMATRIPTAN-D6 HEMISUCCINATE Usage And Synthesis

Biological Activity

Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache.

References

1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999) 2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014)

SUMATRIPTAN-D6 HEMISUCCINATESupplier

ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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sales@chemegen.com
Shanghai isotope chemical co.,ltd
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021-021-51600108 13062666369
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sales@chinaisotope.com
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com