(1R,2S)-2-fluorocyclopropanecarboxylic acid Chemical Properties

Boiling point:

202.3±33.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

pka

4.00±0.11(Predicted)

InChI

InChI=1S/C4H5FO2/c5-3-1-2(3)4(6)7/h2-3H,1H2,(H,6,7)/t2-,3-/m0/s1

InChIKey

HZQKMZGKYVDMCT-HRFVKAFMSA-N

SMILES

[C@H]1(C(O)=O)C[C@@H]1F

Safety Information

HS Code 

2916200090

(1R,2S)-2-fluorocyclopropanecarboxylic acid Usage And Synthesis

Synthesis

Dissolve benzyl alcohol and allyl bromide in the solvent, add sodium hydride, and perform a condensation reaction to obtain allyl benzyl ether. The obtained allyl benzyl ether, dichlorofluoromethane, and sodium hydroxide solution are raw materials for carbene reaction to obtain 2-chloro-2-fluorocyclopropylmethyl benzyl ether. Subsequently, the obtained 2-chloro-2-fluorocyclopropylmethylbenzyl ether is hydrogenated and reduced to obtain 2-chloro-2-fluorocyclopropanemethanol. Sodium hypochlorite is added as an oxidizing agent to perform an oxidation reaction to obtain 2-chloro-2-fluorocyclopropanecarboxylic acid. Finally, diethylamine is added to perform a hydrogenation reduction reaction to obtain (1R,2S)-2-fluorocyclopropanecarboxylic acid.

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