Thalidezine
Thalidezine Basic information
- Product Name:
- Thalidezine
- Synonyms:
-
- Thalidezine
- 5-O-DeMethylhernandezine
- Thalidesine
- 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-20-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-
- Thalidezine USP/EP/BP
- CAS:
- 18251-36-0
- MF:
- C38H42N2O7
- MW:
- 638.75
- Mol File:
- 18251-36-0.mol
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Thalidezine Chemical Properties
- Melting point:
- 158-159℃
- Boiling point:
- 735.0±60.0 °C(Predicted)
- Density
- 1.206±0.06 g/cm3 (20 ºC 760 Torr)
- pka
- 9.71±0.20(Predicted)
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Thalidezine Usage And Synthesis
Description
A further alkaloid of the bisbenzylisoquinoline type found in Thalictrum fendleri Engelm, this base yields colourless crystals from Me2CO and has [α]25D + 236° (CHCl3). The ultraviolet spectrum has one absorption maximum at 283 mJ.1. The D-methyl ether is identical with Hernandezine (q.v.). The D-ethy1 ether forms colourless crystals with m.p. 117-120° C.
Uses
Thalidezine is an isoquinoline alkaloid used in the treatments of cancers and neurodegenerative diseases.
References
Shamma, Shine, Dudock., Tetrahedron, 23, 2887 (1967)
ThalidezineSupplier
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