(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Basic information
- Product Name:
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- Synonyms:
-
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone
- Idelalisib INT
- CAL-101 (N-1) Intermediate
- (S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- CAL10
- IdelalisibIntermediates 1
- 2-[(1S)-1-aminopropyl]-5-fluoro-3-phenyl-3,4-dihydroquinazolin-4-one
- CAS:
- 870281-86-0
- MF:
- C17H16FN3O
- MW:
- 297.33
- Product Categories:
-
- intermediate
- intermediates
- Mol File:
- 870281-86-0.mol
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(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Chemical Properties
- Boiling point:
- 455.3±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethanol (Sparingly)
- form
- Solid
- pka
- 8.23±0.29(Predicted)
- color
- Off-White
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(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Usage And Synthesis
Uses
2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone is used as reagent/reactant in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step.
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-oneSupplier
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