7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties

Melting point:

277-278 °C (decomp)

Boiling point:

461.5±45.0 °C(Predicted)

Density 

1.600±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

0.1 M NaOH: 13.7 mg/mL

form 

solid

pka

0.90±0.30(Predicted)

color 

tan

CAS DataBase Reference

18000-24-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Usage And Synthesis

Target

 Ki: 0.59 μM (reuptake of glutamate)    IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)

Uses

NMDA receptor antagonist at the glycine site

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Biological Functions

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

storage

Room temperature

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL(18000-24-3)Related Product Information

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