7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Target

Product Name: 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
CAS No.: 18000-24-3
Chemical Name: 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
Synonyms: 7-CKA;7-CL-KYNA;7-CHLOROKYNURENIC ACID;7-Chloroquinurenic acid;Kynurenic Acid Impurity 1;7-Chlorokynurenic acid (7-CKA);7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid;7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
CBNumber: CB4263777
Molecular Formula: C10H6ClNO3
Formula Weight: 223.61
MOL File: 18000-24-3.mol

More

Less

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Property

Melting point:: 277-278 °C (decomp)
Boiling point:: 461.5±45.0 °C(Predicted)
Density: 1.600±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: 0.1 M NaOH: 13.7 mg/mL
form: solid
pka: 0.90±0.30(Predicted)
color: tan
CAS DataBase Reference: 18000-24-3(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J61359
Product name: 7-Chlorokynurenic acid, 99+%
Packaging: 10mg
Price: $174.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61359
Product name: 7-Chlorokynurenic acid, 99+%
Packaging: 50mg
Price: $327.65
Updated: 2024/03/01

Tocris

Product number: 0237
Product name: 7-Chlorokynurenicacid
Purity: ≥98%(HPLC)
Packaging: 50
Price: $360
Updated: 2021/12/16

Tocris

Product number: 0237
Product name: 7-Chlorokynurenicacid
Purity: ≥98%(HPLC)
Packaging: 10
Price: $86
Updated: 2021/12/16

TRC

Product number: C366958
Product name: 7-Chlorokynurenicacid
Packaging: 25mg
Price: $160
Updated: 2021/12/16

More

Less

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties,Usage,Production

Target

Ki: 0.59 μM (reuptake of glutamate) IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)

Uses

NMDA receptor antagonist at the glycine site

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Biological Functions

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

storage

Room temperature

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Suppliers

China 45 Europe 1 Germany 3 Japan 1 South Korea 1 Switzerland 2 United Kingdom 6 United States 12 USA 1 Global 72

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9911
Advantage: 50

Shanghai Uchem Inc.

Tel: 15618758386 15618758386
Fax: QQ:3004479444
Email: sales3@myuchem.com
Country: China
ProdList: 2021
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9293
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15952
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Shanghai Maruhua Science and Technology Co. Ltd.

Tel: 18721745940
Fax: QQ1139783351
Email: sales2@api-chem.com
Country: China
ProdList: 1778
Advantage: 58

18000-24-3, 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCLRelated Search:

Trichloroisocyanuric acid 5-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL 5,7-DICHLOROKYNURENIC ACID SODIUM SALT 5,7-DICHLORO-4-HYDROXY-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER METHYL 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLATE 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL DICHLOROKYNURENIC ACID, 5,7-[3-3H]-

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLOROKYNURENIC ACID

7-CHLOROKYNURENIC ACID HYDROCHLORIDE

7-CL-KYNA

7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA

7-Chloro-4-hydroxy-2-quinolinecarboxylic acid

7-Chloroquinurenic acid

7-CKA

7-chloro-4-keto-1H-quinoline-2-carboxylic acid

7-chloro-4-oxo-1H-quinoline-2-carboxylic acid

7-Chloro-4-hydroxyquinoline-2-carboxylic acid hydrochloride

7-Chlorokynurenic acid (7-CKA)

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID

2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-

Kynurenic Acid Impurity 1

18000-24-3

C10H6CINO3

pharmacetical

Glutamate

Glutamate receptor