7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

ChemicalBook > CAS DataBase List > 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Target

Product Name: 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
CAS No.: 18000-24-3
Chemical Name: 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
Synonyms: 7-CKA;7-CL-KYNA;7-CHLOROKYNURENIC ACID;7-Chloroquinurenic acid;Kynurenic Acid Impurity 1;7-Chlorokynurenic acid (7-CKA);7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid;7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
CBNumber: CB4263777
Molecular Formula: C10H6ClNO3
Formula Weight: 223.61
MOL File: 18000-24-3.mol

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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Property

Melting point:: 277-278 °C (decomp)
Boiling point:: 461.5±45.0 °C(Predicted)
Density: 1.600±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: 0.1 M NaOH: 13.7 mg/mL
form: solid
pka: 0.90±0.30(Predicted)
color: tan
CAS DataBase Reference: 18000-24-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J61359
Product name: 7-Chlorokynurenic acid, 99+%
Packaging: 10mg
Price: $174.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61359
Product name: 7-Chlorokynurenic acid, 99+%
Packaging: 50mg
Price: $327.65
Updated: 2024/03/01

Tocris

Product number: 0237
Product name: 7-Chlorokynurenicacid
Purity: ≥98%(HPLC)
Packaging: 50
Price: $360
Updated: 2021/12/16

Tocris

Product number: 0237
Product name: 7-Chlorokynurenicacid
Purity: ≥98%(HPLC)
Packaging: 10
Price: $86
Updated: 2021/12/16

TRC

Product number: C366958
Product name: 7-Chlorokynurenicacid
Packaging: 25mg
Price: $160
Updated: 2021/12/16

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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties,Usage,Production

Target

Ki: 0.59 μM (reuptake of glutamate) IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)

Uses

NMDA receptor antagonist at the glycine site

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Biological Functions

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

storage

Room temperature

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Suppliers

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18000-24-3, 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCLRelated Search:

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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLOROKYNURENIC ACID

7-CHLOROKYNURENIC ACID HYDROCHLORIDE

7-CL-KYNA

7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA

7-Chloro-4-hydroxy-2-quinolinecarboxylic acid

7-Chloroquinurenic acid

7-CKA

7-chloro-4-keto-1H-quinoline-2-carboxylic acid

7-chloro-4-oxo-1H-quinoline-2-carboxylic acid

7-Chloro-4-hydroxyquinoline-2-carboxylic acid hydrochloride

7-Chlorokynurenic acid (7-CKA)

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID

2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-

Kynurenic Acid Impurity 1

18000-24-3

C10H6CINO3

pharmacetical

Glutamate

Glutamate receptor