7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

ChemicalBook > CAS DataBase List > 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Target

Product Name: 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
CAS No.: 18000-24-3
Chemical Name: 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
Synonyms: 7-CKA;7-CL-KYNA;7-CHLOROKYNURENIC ACID;7-Chloroquinurenic acid;Kynurenic Acid Impurity 1;7-Chlorokynurenic acid (7-CKA);7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid;7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
CBNumber: CB4263777
Molecular Formula: C10H6ClNO3
Formula Weight: 223.61
MOL File: 18000-24-3.mol

Less

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Property

Melting point:: 277-278 °C (decomp)
Boiling point:: 461.5±45.0 °C(Predicted)
Density: 1.600±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: 0.1 M NaOH: 13.7 mg/mL
form: solid
pka: 0.90±0.30(Predicted)
color: tan
CAS DataBase Reference: 18000-24-3(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J61359
Product name: 7-Chlorokynurenic acid, 99+%
Packaging: 10mg
Price: $174.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61359
Product name: 7-Chlorokynurenic acid, 99+%
Packaging: 50mg
Price: $327.65
Updated: 2024/03/01

Tocris

Product number: 0237
Product name: 7-Chlorokynurenicacid
Purity: ≥98%(HPLC)
Packaging: 50
Price: $360
Updated: 2021/12/16

Tocris

Product number: 0237
Product name: 7-Chlorokynurenicacid
Purity: ≥98%(HPLC)
Packaging: 10
Price: $86
Updated: 2021/12/16

TRC

Product number: C366958
Product name: 7-Chlorokynurenicacid
Packaging: 25mg
Price: $160
Updated: 2021/12/16

Less

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties,Usage,Production

Target

Ki: 0.59 μM (reuptake of glutamate) IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)

Uses

NMDA receptor antagonist at the glycine site

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Biological Functions

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

storage

Room temperature

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Preparation Products And Raw materials

Raw materials

Preparation Products

Less

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Suppliers

China 44 Europe 1 Germany 3 Japan 1 South Korea 1 Switzerland 2 United Kingdom 6 United States 14 USA 1 Global 73

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shanghai Uchem Inc.

Tel: 15618758386 15618758386
Fax: QQ:3004479444
Email: sales3@myuchem.com
Country: China
ProdList: 2001
Advantage: 55

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9353
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Shanghai Maruhua Science and Technology Co. Ltd.

Tel: 021-57171708; 18721745940
Fax: QQ1139783351
Email: sales2@api-chem.com
Country: China
ProdList: 1884
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30239
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 17691182729 18161915376
Email: 1046@dideu.com
Country: China
ProdList: 10001
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188 13327728092
Email: sales@pharmablock.com
Country: China
ProdList: 9698
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: syeu@accelachem.com
Country: China
ProdList: 11710
Advantage: 58

Nanjing Bic Biotechnology Co., Ltd

Tel: 025-58906079 17352406906
Email: sales@bicbiotech.com
Country: China
ProdList: 7852
Advantage: 58

guoyungurui

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 10335
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 73043
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

LEAP CHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 24727
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Beijing Sizhengbai Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: marketing@4abio.com
Country: CHINA
ProdList: 6401
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Yupu Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: 2439781853@qq.com
Country: CHINA
ProdList: 1328
Advantage: 58

Shanghai Haoyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 596799915@QQ.COM
Country: CHINA
ProdList: 2905
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6158
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

DeBioChem

Tel: --
Fax: --
Email: descibio@sohu.com
Country: China
ProdList: 3333
Advantage: 34

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

18000-24-3, 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCLRelated Search:

Trichloroisocyanuric acid 5-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL 5,7-DICHLOROKYNURENIC ACID SODIUM SALT 5,7-DICHLORO-4-HYDROXY-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER METHYL 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLATE 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL DICHLOROKYNURENIC ACID, 5,7-[3-3H]-

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLOROKYNURENIC ACID

7-CHLOROKYNURENIC ACID HYDROCHLORIDE

7-CL-KYNA

7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA

7-Chloro-4-hydroxy-2-quinolinecarboxylic acid

7-Chloroquinurenic acid

7-CKA

7-chloro-4-keto-1H-quinoline-2-carboxylic acid

7-chloro-4-oxo-1H-quinoline-2-carboxylic acid

7-Chloro-4-hydroxyquinoline-2-carboxylic acid hydrochloride

7-Chlorokynurenic acid (7-CKA)

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID

2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-

Kynurenic Acid Impurity 1

18000-24-3

C10H6CINO3

pharmacetical

Glutamate

Glutamate receptor