7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
Target- Product Name
- 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
- CAS No.
- 18000-24-3
- Chemical Name
- 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
- Synonyms
- 7-CKA;7-CL-KYNA;7-CHLOROKYNURENIC ACID;7-Chloroquinurenic acid;Kynurenic Acid Impurity 1;7-Chlorokynurenic acid (7-CKA);7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid;7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
- CBNumber
- CB4263777
- Molecular Formula
- C10H6ClNO3
- Formula Weight
- 223.61
- MOL File
- 18000-24-3.mol
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Property
- Melting point:
- 277-278 °C (decomp)
- Boiling point:
- 461.5±45.0 °C(Predicted)
- Density
- 1.600±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 0.1 M NaOH: 13.7 mg/mL
- form
- solid
- pka
- 0.90±0.30(Predicted)
- color
- tan
- CAS DataBase Reference
- 18000-24-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- J61359
- Product name
- 7-Chlorokynurenic acid, 99+%
- Packaging
- 10mg
- Price
- $174.65
- Updated
- 2024/03/01
- Product number
- J61359
- Product name
- 7-Chlorokynurenic acid, 99+%
- Packaging
- 50mg
- Price
- $327.65
- Updated
- 2024/03/01
- Product number
- 0237
- Product name
- 7-Chlorokynurenicacid
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 0237
- Product name
- 7-Chlorokynurenicacid
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $86
- Updated
- 2021/12/16
- Product number
- C366958
- Product name
- 7-Chlorokynurenicacid
- Packaging
- 25mg
- Price
- $160
- Updated
- 2021/12/16
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties,Usage,Production
Target
Ki: 0.59 μM (reuptake of glutamate) IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)
Uses
NMDA receptor antagonist at the glycine site
Definition
ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Biological Functions
Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
Biological Activity
NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivo
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
storage
Room temperature