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ChemicalBook > CAS DataBase List > 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

Target
Product Name
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
CAS No.
18000-24-3
Chemical Name
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
Synonyms
7-CKA;7-CL-KYNA;7-CHLOROKYNURENIC ACID;7-Chloroquinurenic acid;Kynurenic Acid Impurity 1;7-Chlorokynurenic acid (7-CKA);7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid;7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
CBNumber
CB4263777
Molecular Formula
C10H6ClNO3
Formula Weight
223.61
MOL File
18000-24-3.mol
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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Property

Melting point:
277-278 °C (decomp)
Boiling point:
461.5±45.0 °C(Predicted)
Density 
1.600±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
0.1 M NaOH: 13.7 mg/mL
form 
solid
pka
0.90±0.30(Predicted)
color 
tan
CAS DataBase Reference
18000-24-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J61359
Product name
7-Chlorokynurenic acid, 99+%
Packaging
10mg
Price
$174.65
Updated
2024/03/01
Alfa Aesar
Product number
J61359
Product name
7-Chlorokynurenic acid, 99+%
Packaging
50mg
Price
$327.65
Updated
2024/03/01
Tocris
Product number
0237
Product name
7-Chlorokynurenicacid
Purity
≥98%(HPLC)
Packaging
50
Price
$360
Updated
2021/12/16
Tocris
Product number
0237
Product name
7-Chlorokynurenicacid
Purity
≥98%(HPLC)
Packaging
10
Price
$86
Updated
2021/12/16
TRC
Product number
C366958
Product name
7-Chlorokynurenicacid
Packaging
25mg
Price
$160
Updated
2021/12/16
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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties,Usage,Production

Target

 Ki: 0.59 μM (reuptake of glutamate)    IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)

Uses

NMDA receptor antagonist at the glycine site

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Biological Functions

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

storage

Room temperature

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Suppliers

18000-24-3, 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCLRelated Search:


  • 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
  • 7-CHLOROKYNURENIC ACID
  • 7-CHLOROKYNURENIC ACID HYDROCHLORIDE
  • 7-CL-KYNA
  • 7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA
  • 7-Chloro-4-hydroxy-2-quinolinecarboxylic acid
  • 7-Chloroquinurenic acid
  • 7-CKA
  • 7-chloro-4-keto-1H-quinoline-2-carboxylic acid
  • 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
  • 7-Chloro-4-hydroxyquinoline-2-carboxylic acid hydrochloride
  • 7-Chlorokynurenic acid (7-CKA)
  • 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
  • 2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-
  • Kynurenic Acid Impurity 1
  • 18000-24-3
  • C10H6CINO3
  • pharmacetical
  • Glutamate
  • Glutamate receptor