Methyl 2-Methyl-6-quinolinecarboxylate Chemical Properties

Melting point:

103-105 °C

Boiling point:

320.3±22.0 °C(Predicted)

Density 

1.177±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

4.90±0.43(Predicted)

color 

Light grey

InChI

InChI=1S/C12H11NO2/c1-8-3-4-9-7-10(12(14)15-2)5-6-11(9)13-8/h3-7H,1-2H3

InChIKey

KGSIXOOGGCSYTB-UHFFFAOYSA-N

SMILES

N1C2C(=CC(C(OC)=O)=CC=2)C=CC=1C

Safety Information

HS Code 

2933499090

Methyl 2-Methyl-6-quinolinecarboxylate Usage And Synthesis

Synthesis

Step 2: Synthesis of methyl 2-methylquinoline-6-carboxylate: 2-methyl-6-quinolinecarboxylic acid (3.0 g, 16.20 mmol) was dissolved in methanol (30 mL) at 0°C and concentrated sulfuric acid (3 mL) was added slowly and dropwise. Subsequently, the reaction mixture was warmed to 65°C and stirred continuously for 12 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure. The concentrated residue was extracted by adding dichloromethane and aqueous sodium carbonate to the concentrated residue. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford methyl 2-methylquinoline-6-carboxylate as a brown solid (1.9 g, 59% yield).

References

[1] Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 929 - 931
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 40, p. 12224 - 12227
[3] Angew. Chem., 2016, vol. 128, # 40, p. 12412 - 12415,4
[4] Patent: WO2013/144737, 2013, A2. Location in patent: Paragraph 252
[5] Patent: US2015/57309, 2015, A1. Location in patent: Paragraph 0525

Methyl 2-Methyl-6-quinolinecarboxylate(108166-01-4)Related Product Information

• 4-Aminomethylquinoline hydrochloride
• 2-HYDROXY-4-METHYLQUINOLINE